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General Information

Placing Lab Orders

Collecting Lab Specimens

Lab Section-Specific Information

 

 

Mayo Clinic Laboratories

Chloride Sweat Analysis

eD-H Order Code

O16431 or LAB1726

Specimen Collection Information

Specimen Minimum Test Volume Container Special Handling
Body Fl 1.0 ML Sweat Vial Schedule before draw

Specimen Transport Temperature

Ambient

Reference Ranges / Critical Values

Assay Gender Age Range Normal Range Critical Values Units
Chloride Sweat All 0 Minutes – 150 Years ≤29   mMol/L

Specimen Stability


Chemistry Blood and Urine Analyte Stability Chart

Additional Specimen Instructions

Schedule at least 48 hours in advance. This test must be pre-scheduled with the pediatric clinic.
The clinic will then coordinate with the Chemistry Lab.

Interpretive Data

Assay Display Interpretive Data
Chloride Sweat

≤29 mmol/L: CF unlikely
30-59 mmol/L: intermediate
≥60 mmol/L: indicative of CF

In infants presenting with a positive newborn screening test and CFTR genotype demonstrating the presence of 2 CF-causing mutations, clinical features consistent with CF, or a positive family history, a single sweat chloride concentration of ≥ 60 mmol/L is sufficient to confirm the diagnosis. Individuals with a sweat chloride in the intermediate range (30 – 59 mmol/L) will need further study to establish or rule out a CF diagnosis.  A normal sweat chloride value (≤29 mmol/L) cannot be used as the sole criterion for exclusion of a CF diagnosis.

Day(s) Performed

Monday through Friday; must be scheduled with Pediatric Clinic

CPT(s)

82438

Performing Lab Section

Chemistry