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Platelet Function Analysis

Important Note

DO NOT TRANSPORT VIA THE PNEUMATIC TUBE SYSYEM.

Call Distribution at ext 5-6101 for transport.

Patient must be present at the DH-Lebanon campus for phlebotomy.

eD-H Order Code

LAB318

Specimen Collection Information

Specimen Minimum Test Volume Container Special Handling
Blood 6.0 ML NO SPIN/NO TUBE

Specimen Transport Temperature

Ambient

Patient must be present at the D-H Lebanon Campus for phlebotomy

 

Reference Ranges / Critical Values

Assay Gender Age Range Normal Range Critical Values Units
Col/ADP All 0 Minutes – 150 Years ≤120   sec
Col/Epi All 0 Minutes – 150 Years ≤160   sec

Specimen Stability

3 hours

Additional Specimen Instructions

Do not send through pneumatic tube system


Do not centrifuge

 

2.7 mL Sodium Citrate tube filled to the line

Collect TWO 2.7 mL Blue top tubes

Interpretive Data

Assay Display Interpretive Data
Col/Epi The PFA-100 test result is dependent on platelet function plasma von Willebrand factor level platelet number and the hematocrit. The PFA-100 test is initially performed with the Col/Epi cartridge. A normal Col/Epi closure time (≤160 seconds) excludes the presence of a significant platelet function defect and the Col/ADP test is not performed. If the Col/Epi closure time is prolonged (>160 seconds) the Col/ADP test is automatically performed. If the Col/ADP result is normal (≤120 seconds) then drug-induced platelet dysfunction is most likely (e.g. due to aspirin NSAIDs). Prolongation of both test results (Col/Epi >160 seconds Col/ADP >120 seconds) may indicate the presence of a hereditary or acquired qualitative platelet disorder though long term aspirin treatment may sometimes cause a modestly prolonged Col/ADP closure time. Additionally anemia and thrombocytopenia will result in prolonged closure times for both tests. Once aspirin use anemia and thrombocytopenia have been excluded further evaluation to exclude von Willebrand disease and inherited/acquired platelet dysfunction (e.g. due to uremia platelet storage pool disorders release defects Bernard-Soulier disease and Glanzmann thromboasthenia) should be considered.

Additional Testing Information

Blue top tube must be filled within 10% of the stated volume. A discard tube must be used if a citrate tube is to be drawn using a winged blood collection set. It is important to remove air from the blood collection set to ensure the proper blood volume is obtained in the coag tube.

 

If the patient has a known hematocrit >55%, please contact the coagulation lab for an adjusted tube before drawing the blood.

CPT(s)

85576

Performing Lab Section

Hematology