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HelpEstrogens, Estrone (E1) and Estradiol (E2), Fractionated, Serum
Additional Codes
LAB981
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| E1 | Estrone, S | Yes | Yes |
| EEST | Estradiol, Mass Spectrometry, S | Yes | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube: Red top (Serum gel/SST is not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume:1.2 mL
Collection Instructions: Within 2 hours of collection centrifuge and aliquot serum in plastic vial within 2 hours of collection.
Additional Information: For more information see Steroid Pathways.
Specimen Minimum Volume
0.7mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
ESTRONE (E1)
CHILDREN*
1 to14 days: Estrone levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-16 pg/mL |
|
Stage II |
11.5 years |
Undetectable-22 pg/mL |
|
Stage III |
13.6 years |
10-25 pg/mL |
|
Stage IV |
15.1 years |
10-46 pg/mL |
|
Stage V |
18 years |
10-60 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (± 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-29 pg/mL |
|
Stage II |
10.5 years |
10-33 pg/mL |
|
Stage III |
11.6 years |
15-43 pg/mL |
|
Stage IV |
12.3 years |
16-77 pg/mL |
|
Stage V |
14.5 years |
17-200 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (± 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature,(1,2) cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-60 pg/mL
Females
Premenopausal: 17-200 pg/mL
Postmenopausal: 7-40 pg/mL
Conversion factor
E1: pg/mL x 3.704=pmol/L (molecular weight=270)
ESTRADIOL (E2)
CHILDREN*
1 to14 days: Estradiol levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.
Males
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-13 pg/mL |
|
Stage II |
12.1 years |
Undetectable-16 pg/mL |
|
Stage III |
13.6 years |
Undetectable-26 pg/mL |
|
Stage IV |
15.1 years |
Undetectable-38 pg/mL |
|
Stage V |
18 years |
10-40 pg/mL |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (± 2) years. For boys there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
Females
|
Tanner stages# |
Mean age |
Reference range |
|
Stage I (>14 days and prepubertal) |
7.1 years |
Undetectable-20 pg/mL |
|
Stage II |
10.5 years |
Undetectable-24 pg/mL |
|
Stage III |
11.6 years |
Undetectable-60 pg/mL |
|
Stage IV |
12.3 years |
15-85 pg/mL |
|
Stage V |
14.5 years |
15-350 pg/mL** |
#Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (± 2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) should be reached by age 18.
*The reference ranges for children are based on the published literature,(1,2) cross-correlation of our assay with assays used to generate the literature data and on our data for young adults.
ADULTS
Males: 10-40 pg/mL
Females
Premenopausal: 15-350 pg/mL**
Postmenopausal: <10 pg/mL
**E2 levels vary widely through the menstrual cycle.
Conversion factor
E2: pg/mL x 3.676=pmol/L (molecular weight=272)
For International System of Units (SI) conversion for Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) Performed
Monday through Saturday
CPT Code Information
82671-Estrogens, fractionated
82670-Estradiol (If applicable)
82679-Estrone (If applicable)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ESTF | Estrogens, E1+E2, fractionated, S | 53766-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 81418 | Estrone, S | 2258-2 |
| 81816 | Estradiol, Mass Spectrometry, S | 2243-4 |