5-Hydroxyindoleacetic Acid, 24 Hour, Urine

Additional Codes

LAB352

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine

Ordering Guidance

This test is the preferred test for measurement of 5-hydroxyindoleacetic acid concentrations. If a random urine collection is preferred, order HIAAR / 5-Hydroxyindoleacetic Acid, Random, Urine.

Necessary Information

1. Collection duration and urine volume in milliliters are required.

2. Patient's age and sex are required.

Specimen Required

Patient Preparation:

1. Some medications could interfere with test results. The ordering provider should decide if any medications should be stopped and when they should be restarted. If clinically feasible, discontinue the following medications at least 48 hours prior to, as well as during, specimen collection:

-Acetaminophen (Tylenol or generic versions)

-Tryptophan containing supplements

2. For 48 hours prior to, as well as during, the urine collection, the patient should:

Limit the following to one serving per day:

-Fruits

-Vegetables

-Nuts

-Caffeinated beverages or foods

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 5 mL

Collection Instructions:

1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old.

2. Collect a 24-hour urine specimen.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type	Temperature	Time	Special Container
Urine	Refrigerated (preferred)	56 days
	Frozen	365 days

Special Instructions

Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens

Reference Values

	5-HIAA, mg/24 hour 99th percentile cutoff
Age	Female	Male
≤23 months	≤2.7	≤2.3
24-35 months	≤3.0	≤2.6
3 years	≤3.2	≤2.9
4 years	≤3.4	≤3.2
5 years	≤3.6	≤3.6
6 years	≤3.8	≤3.9
7 years	≤4.0	≤4.2
8 years	≤4.2	≤4.5
9 years	≤4.5	≤4.8
10 years	≤4.7	≤5.1
11 years	≤4.9	≤5.3
12 years	≤5.2	≤5.6
13 years	≤5.4	≤5.8
14 years	≤5.6	≤6.1
15 years	≤5.7	≤6.3
16 years	≤5.9	≤6.4
17 years	≤6.0	≤6.6
18 years	≤6.0	≤6.7
19 years	≤6.1	≤6.8
20 years	≤6.1	≤6.9
21 years	≤6.2	≤6.9
22 years	≤6.2	≤7.0
23 years	≤6.2	≤7.0
24 years	≤6.3	≤7.1
25 years	≤6.3	≤7.2
26 years	≤6.3	≤7.2
27 years	≤6.4	≤7.3
28 years	≤6.4	≤7.4
29 years	≤6.5	≤7.5
30 years	≤6.6	≤7.5
31 years	≤6.6	≤7.6
32 years	≤6.7	≤7.7
33 years	≤6.8	≤7.7
34 years	≤6.8	≤7.8
35 years	≤6.9	≤7.9
36 years	≤6.9	≤7.9
37 years	≤7.0	≤8.0
38 years	≤7.0	≤8.1
39 years	≤7.0	≤8.2
40 years	≤7.1	≤8.2
41 years	≤7.1	≤8.3
42 years	≤7.2	≤8.4
43 years	≤7.3	≤8.5
44 years	≤7.4	≤8.6
45 years	≤7.4	≤8.7
46 years	≤7.5	≤8.8
47 years	≤7.6	≤8.9
48 years	≤7.6	≤9.0
49 years	≤7.7	≤9.1
50 years	≤7.7	≤9.2
51 years	≤7.8	≤9.3
52 years	≤7.8	≤9.4
53 years	≤7.9	≤9.5
54 years	≤8.0	≤9.6
55 years	≤8.1	≤9.7
56 years	≤8.1	≤9.7
57 years	≤8.2	≤9.8
58 years	≤8.3	≤9.8
59 years	≤8.3	≤9.8
60 years	≤8.3	≤9.9
61 years	≤8.3	≤9.9
62 years	≤8.4	≤9.9
63 years	≤8.4	≤10.0
64 years	≤8.4	≤10.0
65 years	≤8.4	≤10.0
66 years	≤8.5	≤10.1
67 years	≤8.5	≤10.1
68 years	≤8.5	≤10.1
69 years	≤8.5	≤10.2
70 years	≤8.5	≤10.2
71 years	≤8.6	≤10.2
72 years	≤8.6	≤10.2
73 years	≤8.5	≤10.1
74 years	≤8.5	≤10.1
75 years	≤8.6	≤10.1
76 years	≤8.6	≤10.0
77 years	≤8.6	≤10.0
78 years	≤8.6	≤10.0
79 years	≤8.6	≤10.0
80 years	≤8.7	≤9.9
81 years	≤8.7	≤9.9
82 years	≤8.7	≤9.9
83 years	≤8.7	≤9.9
84 years	≤8.7	≤9.9
85 years	≤8.6	≤9.8
86 years	≤8.5	≤9.8
87 years	≤8.4	≤9.7
88 years	≤8.3	≤9.7
89 years	≤8.1	≤9.5
90 years	≤7.9	≤9.4
91 years	≤7.6	≤9.2
92 years	≤7.4	≤9.0
93 years	≤7.1	≤8.8
94 years	≤7.0	≤8.7
= 95 years	≤6.9	≤8.6

For SI unit Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) Performed

Monday through Friday

CPT Code Information

83497

LOINC Code Information

Test ID	Test Order Name	Order LOINC Value
HIAA	5-Hydroxyindoleacetic Acid, U	1695-6

Result ID	Test Result Name	Result LOINC Value
9248	5-Hydroxyindoleacetic Acid, U	1695-6
TM35	Collection Duration	13362-9
VL33	Urine Volume	3167-4

Report Available

2 to 4 days

Specimen Retention Time

7 days

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

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