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HelpNucleophosmin (NPM1) Mutation Analysis, Varies
Additional Codes
LAB4272 (bone marrow only)
Shipping Instructions
1. Refrigerated specimens must arrive within 5 days of collection, and ambient specimens must arrive within 3 days of collection.
2. Collect and package specimen as close to shipping time as possible.
Necessary Information
The following information is required:
1. Pertinent clinical history
2. Clinical or morphologic suspicion
3. Specimen source (blood or bone marrow)
Specimen Required
Submit only 1 of the following specimens:
Specimen Type: Blood
Container/Tube: Lavender top (EDTA) or yellow top (ACD-B)
Specimen Volume: 10 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
3. Label specimen as blood.
Specimen Type: Bone marrow
Container/Tube: Lavender top (EDTA) or yellow top (ACD-B)
Specimen Volume: 4 mL
Collection Instructions:
1. Invert several times to mix bone marrow.
2. Send bone marrow specimen in original tube. Do not aliquot.
3. Label specimen as bone marrow.
Forms
1. Hematopathology Patient Information (T676)
2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.
Special Instructions
Specimen Type
VariesSpecimen Minimum Volume
Blood: 8 mL; Bone marrow: 2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Refrigerated (preferred) | 5 days | |
| Ambient | 72 hours |
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Saturday
Report Available
10 to 14 daysSpecimen Retention Time
Blood/bone marrow: 2 weeks; Extracted DNA and RNA: 3 monthsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
81310-NPM1 (nucleophosmin) (eg, acute myeloid leukemia) gene analysis; exon 12 variants
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| NPM1Q | NPM1 Mutation Analysis, V | 54448-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| MP053 | Specimen Type | 31208-2 |
| 605098 | Interpretation | 59466-3 |
| 605262 | Signing Pathologist | 19139-5 |