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Hematologic Neoplasms, TP53 Somatic Mutation, DNA Sequencing Exons 4-9, Varies

Specimen Type

Varies


Ordering Guidance


For the evaluation of patients suspected of having an inherited or germline TP53 cancer syndrome (eg, Li Fraumeni syndrome), order one of the following tests containing TP53:

-XCP/ Hereditary Expanded Cancer Panel, Varies

-COMCP / Hereditary Common Cancer Panel, Varies

-BRGYP / Hereditary Breast/Gynecologic Cancer Panel, Varies

-CRCGP / Hereditary Gastrointestinal Cancer Panel, Varies

-PANCP / Hereditary Pancreatic Cancer Panel, Varies

-ENDCP / Hereditary Endocrine Cancer Panel, Varies

-THYRP / Hereditary Thyroid Cancer Panel, Varies

-WILMP / Hereditary Wilms Tumor Panel, Varies

-RENCP / Hereditary Renal Cancer Panel, Varies

-PRS8P / Hereditary Prostate Cancer Panel, Varies



Shipping Instructions


Blood and bone marrow specimens must arrive within 10 days of collection.



Necessary Information


The following information is required:

1. Pertinent clinical history

2. Clinical or morphologic suspicion

3. Date of collection

4. Specimen source



Specimen Required


Submit only 1 of the following specimens:

 

Specimen Type: Blood (preferred)

Container/Tube: Lavender top (EDTA) or yellow top (ACD solution B)

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send whole blood specimen in original tube. Do not aliquot.

3. Label specimen as blood.

Specimen Stability Information: Ambient/Refrigerate <10 days

 

Specimen Type: Bone marrow

Container/Tube: Lavender top (EDTA), yellow top (ACD solution B), or green top (heparin)

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send bone marrow specimen in original tube. Do not aliquot.

3. Label specimen as bone marrow.

Specimen Stability Information: Ambient/Refrigerate <10 days

 

Specimen Type: Tissue

Container/Tube: Plastic container

Specimen Volume: 100 mg

Collection Instructions: Stabilize fresh tissue in tissue culture medium or freeze immediately after collection.

Specimen Stability Information: Refrigerate 24 hours/ Frozen


Specimen Minimum Volume

Blood, bone marrow: 1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies 10 days

Reference Values

Genetic variants present or absent as compared to a reference sequence of the normal TP53 gene

Day(s) Performed

Monday through Friday

Report Available

8 to 14 days

Specimen Retention Time

Blood/Bone marrow: 2 weeks; Extracted DNA 3 months

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

81352-TP53 (tumor protein 53) (eg, tumor samples), full gene sequence or targeted sequence analysis of >5 exons

LOINC Code Information

Test ID Test Order Name Order LOINC Value
P53CA TP53 gene somatic mutation analysis 21739-8

 

Result ID Test Result Name Result LOINC Value
MP018 Specimen Type: 31208-2
607075 Signing Pathologist 19139-5
35759 Final Diagnosis: 34574-4

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
CSP53 TP53 Pre-Analysis Cell Sorting, V No No