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HelpRenin Activity, Plasma
Additional Codes
LAB532
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Plasma EDTASpecimen Required
Patient Preparation: For 4 to 6 weeks before specimen collection, spironolactone (Aldactone) should be discontinued, as plasma renin activity cannot be interpreted if the patient is being treated with spironolactone.
Collection Container/Tube: Chilled, lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 0.8 mL
Collection Instructions:
1. Draw blood in a chilled syringe from a patient in a seated position; place specimen in a chilled, 3-mL lavender-top (EDTA) tube and mix well. Alternatively, draw blood directly in a chilled, EDTA tube.
2. Immediately place EDTA tube into an ice-water bath until thoroughly cooled.
3. Immediately centrifuge using a refrigerated centrifuge and aliquot plasma into a plastic vial.
Note: If a refrigerated centrifuge is unavailable, chill the centrifuge carriers before use. Centrifuge specimen for 5 minutes or less, then promptly aliquot plasma into a plastic vial.
4. Immediately freeze plasma.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Frozen | 14 days |
Special Instructions
Reference Values
0-2 years: 4.6 ng/mL/h (mean)* Range: 1.4-7.8 ng/mL/h
3-5 years: 2.5 ng/mL/h (mean)* Range: 1.5-3.5 ng/mL/h
6-8 years: 1.4 ng/mL/h (mean)* Range: 0.8-2.0 ng/mL/h
9-11 years: 1.9 ng/mL/h (mean)* Range: 0.9-2.9 ng/mL/h
12-17 years: 1.8 ng/mL/h (mean)* Range: 1.2-2.4 ng/mL/h
Mean data not standardized as to time of day or diet. Infants were supine, children sitting.
*Stalker HP, Holland NH, Kotchen JM, Kotchen TA. Plasma renin activity in healthy children. J Pediatr. 1976;89(2):256-258
Na-depleted, upright (peripheral vein specimen)
18-39 years: 10.8 ng/mL/h (mean)
2.9-24.0 ng/mL/h (range)
≥40 years: 5.9 ng/mL/h (mean)
2.9-10.8 ng/mL/h (range)
Na-replete, upright (peripheral vein specimen)
18-39 years: 1.9 ng/mL/h (mean)
≤0.6-4.3 ng/mL/hour (range)
≥40 years: 1.0 ng/mL/h (mean)
≤0.6-3.0 ng/mL/h (range)
Day(s) Performed
Monday through Friday, Sunday
CPT Code Information
84244
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PRA | Renin Activity, P | 2915-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8060 | Renin Activity, P | 2915-7 |
Report Available
2 to 5 daysSpecimen Retention Time
14 daysForms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Cardiovascular Test Request (T724)