dRVVT

Important Note

Included as part of the Lupus Anticoagulant Panel

Specimen Collection Information

Specimen	Minimum Test Volume	Container	Special Handling
Blood	PEDI, PICU, or ICN draws refer to specimen collection job aid. All other Coag tubes must be filled to the line on tube.

Specimen

Minimum Test Volume

Container

Special Handling

Blood

PEDI, PICU, or ICN draws refer to specimen collection job aid.

All other Coag tubes must be filled to the line on tube.

Specimen Transport Temperature

Double spin, separate, and freeze

Reference Ranges / Critical Values

Assay	Gender	Age Range	Normal Range	Critical Values	Units
dRVVT	All	0 Minutes – 150 Years	<1.20		IU/mL

Specimen Stability

4 hours

Additional Specimen Instructions

1.8 mL Sodium Citrate tube filled to the line

2.7 mL Sodium Citrate tube filled to the line

Blue top tubes must be filled within 10% of stated volume. A discard tube must be used if a citrate tube is to be drawn using a winged blood collection set. It is important to remove air from the blood collection set to ensure the proper blood volume is obtained in the coag tube.

If the patient has a known hematocrit >55%, please contact the coagulation lab for an adjusted collection tube before drawing the blood.

Interpretive Data

Assay Display	Interpretive Data
dRVVT	A normal Dilute Russell viper venom time (dRVVT) ratio (<1.20) indicates that a lupus anticoagulant (LA) is not present or not detectable by this method (but might be detected with other methods). Because of the heterogeneous nature of LA antibodies no single coagulation test can identify or exclude all LA. Currently the International Society on Thrombosis and Hemostasis and the Clinical and Laboratory Standards Institute (CLSI) recommend testing for LA with at least 2 phospholipid-dependent clotting time assays based on different coagulation pathways and principles (e.g; SCT and dRVVT). Abnormal dRVVT ratio (dRVVT ratio ≥1.20) may suggest the presence of LA; however other possibilities include: -Coagulation factor deficiencies -Other types of coagulation factor inhibitors -Anticoagulation therapy effects (NOTE: testing at least 1 week from discontinuation of anticoagulation therapy is recommended) The diagnosis of LA requires evidence of persistence of a positive LA over time (≥12 weeks). Repeat dRVVT testing after at least 12 weeks is recommended to confirm the diagnosis.

Assay Display

Interpretive Data

dRVVT

A normal Dilute Russell viper venom time (dRVVT) ratio (<1.20) indicates that a lupus anticoagulant (LA) is not present or not detectable by this method (but might be detected with other methods). Because of the heterogeneous nature of LA antibodies no single coagulation test can identify or exclude all LA. Currently the International Society on Thrombosis and Hemostasis and the Clinical and Laboratory Standards Institute (CLSI) recommend testing for LA with at least 2 phospholipid-dependent clotting time assays based on different coagulation pathways and principles (e.g; SCT and dRVVT). Abnormal dRVVT ratio (dRVVT ratio ≥1.20) may suggest the presence of LA; however other possibilities include: -Coagulation factor deficiencies -Other types of coagulation factor inhibitors -Anticoagulation therapy effects (NOTE: testing at least 1 week from discontinuation of anticoagulation therapy is recommended) The diagnosis of LA requires evidence of persistence of a positive LA over time (≥12 weeks). Repeat dRVVT testing after at least 12 weeks is recommended to confirm the diagnosis.

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dRVVT

Important Note

Specimen Collection Information

Specimen Transport Temperature

Reference Ranges / Critical Values

Specimen Stability

Additional Specimen Instructions

Interpretive Data

CPT(s)

Performing Lab Section

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